Blue curing light

Perhaps Blue (Violet) light can affect the Telomerase dividing activity in certain cells? Interesting how certain reactions in the body are affected by different wavelengths of light.

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A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.

"The light sends wavelengths of blue-violet light to the composite, which triggers hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death."

Mr. Patel, who has been working with Dr. Jill Lewis, associate professor of oral biology, Dr. Regina Messer, associate professor of oral rehabilitation and oral biology, and Dr. John Wataha, adjunct professor of oral rehabilitation and oral biology, studied 10 tumor-bearing mice, five treated with the light and five untreated.

He exposed half the mice to the blue light for 90 seconds a day for 12 days. Then the tumors were extracted and each one was split into two sections. Half were used to create slides for tissue analysis, and half were frozen to prepare protein extracts.

Tissue analysis indicated an approximate 10 percent increase in cell suicide, or apoptosis, in the light-treated tumors. The frozen protein extracts revealed a nearly 80 percent decrease in cell growth in the light-treated tumors.

"The decrease in cell growth, combined with increased apoptosis, helps explain why the tumors didn't grow as much because you have cells that aren't dividing and you have cells that are committing suicide," Mr. Patel says.

Dr. Lewis predicts treating the tumors with blue light sooner will increase the rate of apoptosis, possibly preventing the tumor from ever becoming measurable and easing treatment.

"One desirable feature we've observed with the blue light is that non-cancerous cells appear unaffected at light doses that kill tumor cells," says Dr. Lewis. "We're thinking that some day, blue light therapy may serve as an adjunct to conventional cancer therapy. Patients may, therefore, receive lower doses of chemotherapy, which would decrease the adverse effects most cancer patients experience from standard chemotherapy regimens."

https://www.sciencedaily.com/releases/2008/06/080624110831.htm

What is Special about the Violet Laser Wavelength?

The violet wavelength appears within the range of 405 to 460 nm. This unique wavelength spectrum is capable of carrying way more information than all other wavelengths and has thus made it the preferred choice for data, DVD and CD equipment and more recently for advanced healing equipment. The violet wavelength is also revered for its healing properties, but has not been widely used in the past due to its prohibitively high cost. Due to advancements in technology and competitiveness in the industry, prices of violet LED and Laser equipment have become much more affordable.

Within this light wave window of 405 to 460 exists the ability to stimulate a different kind of healing than with other wavelengths. While Red lasers are great for skin, burns, wounds, inflammation and most soft tissues issues and Infrared (IR) lasers are great for bones, joints, tendons, ligaments and hard tissues of the body, violet laser does something different, and is considered the preferred anti-aging wavelength.

The Violet wavelength of 405 to 460 has been receiving a renewed interest and excitement among those who understand it’s unique characteristics. It is known to induce action in the full group of "cytochrome oxidase enzymes." These enzymes are formed in the mitochondria (structures inside of the cells) and generate the ATP (adenosine triphosphate), which is the basic fuel for the cells to regenerate themselves. This is the key to renewing the vitality of skin.

Many next-generation applications like Bio-Medical instrumentation, high-resolution printing and high-density data storage rely on 405nm, or violet lasers. They also activate chemicals called porphyrins (which are produced by the P. acnes bacteria responsible for causing acne inflammation) creating intracellular singlet oxygen – inducing bacterial cell death. This is often combined with Red low level laser, which has anti inflammatory properties, minimizing the redness of acne lesions and promoting healthier skin.

Correct wavelengths at optimal intensities ensure optimal results.

Violet lasers help to reduce bacterial colonization of the sebaceous gland, reducing sebum production to normal and reducing the production of pro-inflammatory cytokines. Simultaneously, violet wavelengths induce anti-inflammatory cytokines, stimulating specific immuno-regulatory pathways.

Studies have shown combination blue & red phototherapy reduces inflammatory acne lesion count by up to 80%, 12 weeks from the end of treatment.

https://discoverlasers.com/blog/what-special-about-violet-laser-wavelength

Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin

Tianhui Niu ,
Yan Tian ,
Qing Cai,
Qu Ren,
Lizhao Wei

PLOS

Published: September 18, 2015
https://doi.org/10.1371/journal.pone.0138754


Abstract

Curcumin is a widely known natural phytochemical from plant Curcuma longa. In recent years, curcumin has received increasing attention because of its capability to induce apoptosis and inhibit cell proliferation as well as its anti-inflammatory properties in different cancer cells. However, the therapeutic benefits of curcumin are severely hampered due to its particularly low absorption via trans-dermal or oral bioavailability. Phototherapy with visible light is gaining more and more support in dermatological therapy. Red light is part of the visible light spectrum, which is able to deeply penetrate the skin to about 6 mm, and directly affect the fibroblast of the skin dermis. Blue light is UV-free irradiation which is fit for treating chronic inflammation diseases. In this study, we show that curcumin at low concentrations (1.25–3.12 μM) has a strong anti-proliferative effect on TNF-α-induced psoriasis-like inflammation when applied in combination with light-emitting-diode devices. The treatment was especially effective when LED blue light at 405 nm was combined with red light at 630 or 660 nm, which markedly amplified the anti-proliferative and apoptosis-inducing effects of curcumin. The experimental results demonstrated that this treatment reduced the viability of human skin keratinocytes, decreased cell proliferation, induced apoptosis, inhibited NF-κB activity and activated caspase-8 and caspase-9 while preserving the cell membrane integrity. Moreover, the combined treatment also down-regulated the phosphorylation level of Akt and ERK. Taken together, our results indicated that the combination of curcumin with LED blue light united red light irradiation can attain a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138754

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Laser Physics

June 2010, Volume 20, Issue 6, pp 1500–1503 | Cite as
Effect of blue light radiation on curcumin-induced cell death of breast cancer cells

Abstract

In the present study, we have successfully set up a novel blue light source with the power density of 9 mW/cm2 and the wavelength of 435.8 nm and then the novel light source was used to investigate the effect of light radiation on curcumin-induced cell death. The cytotoxicity was investigated 24 h after the treatment of curcumin and blue light radiation together using MTT reduction assay. Nuclear chromatin was observed using a fluorescent microscopy with Hoechst33258 staining. The results showed blue light radiation could significantly enhance the cytotoxicity of curcumin on the MCF-7 cells and apoptosis induction. These findings demonstrated that blue light radiation could enhance curcumin-induced cell death of breast cancer cells, suggesting light radiation may be an efficient enhancer of curcumin in the management of breast cancer.

Keywords
Curcumin Light Radiation Laser Phys Laser Physics Hoechst33258 Staining

https://link.springer.com/article/10.1134%2FS1054660X10110332